A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome - PMC

The Nugget

Berberis vulgaris and its component berberine have demonstrated promise in managing Metabolic Syndrome (MetS) by exerting significant antidiabetic, antiobesity, hypotensive, and hypolipidemic effects.

Key quotes

"A large body of literature supports different pharmacological actions of Berberis vulgaris (B. vulgaris) and its active component, berberine (BBR), such as antidiabetic, antiobesity, hypotensive and hypolipidemic properties that could be interesting in the management of MetS associated with high CVD risk."
"This review suggests a potential role of B. vulgaris and BBR in the managing of MetS; nevertheless more investigations, especially reliable clinical trials, need to be accomplished to evaluate their effectiveness."
"In line with this, “zereshk” which is the Persian name for Berberis vulgaris (B. vulgaris), is extensively cultivated in Iran (typically in Birjand and Qaen cities), central and southern Europe and the northeastern of the United States."
"BBR, a type of isoquinoline alkaloid with a long history of medicinal application, is the major active component of B. vulgaris."

B. vulgaris and berberine significantly reduced serum levels of triglycerides and total cholesterol in both human and animal studies. Mechanisms include enhancing the expression of hepatic LDL receptors and modulating genes involved in lipid metabolism.

B. vulgaris and berberine were found to reduce body weight, fasting blood glucose, and assist in managing insulin resistance in obese subjects through modulation of PPARγ expression, indicating a significant antiobesity effect.

Berberine showed significant hypotensive effects in various studies through mechanisms such as the inhibition of the renin-angiotensin system, pro-inflammatory cytokines, and direct effects on arterial blood pressure.

Several studies have supported the antidiabetic effect of B. vulgaris and berberine, showing reductions in fasting blood glucose, postprandial blood glucose, and improvements in lipid metabolism. This was mediated through multiple pathways including upregulation of insulin receptor expression, modulation of glucose transporter expressions, and enhancement of glycolysis.

🌱 Berberis vulgaris (Barberry) shows diverse therapeutic potential in tackling the components of Metabolic Syndrome.
💊 Berberine, the main alkaloid of Barberry, stands out for its multifaceted approach in managing diabetes, obesity, hypertension, and dyslipidemia.
🔬 Through the activation of AMP kinase and modulation of LDL receptors, berberine effectively combats high cholesterol and glucose levels.
🍇 Cultivated extensively in Iran, Europe, and the USA, Barberry’s traditional and modern medicinal applications offer a holistic approach to preventing cardiovascular diseases.

This summary contains AI-generated information and may have important inaccuracies or omissions.