• Participants consumed a smoothie containing 22.5g of blueberry bioactives twice daily for 6 weeks.
• Insulin sensitivity was measured using a high-dose hyperinsulinemic-euglycemic clamp.
• Participants in both the blueberry and placebo groups were advised to maintain their body weight by adjusting their food intake accordingly.
• Study design: double-blinded, randomized, placebo-controlled clinical study.

• Bioactives: Compounds in foods or dietary supplements that exert a biological effect on the body.
• Hyperinsulinemic-euglycemic clamp: A method to measure insulin sensitivity by maintaining a stable blood glucose level while infusing insulin.
• Adiposity: The amount of body fat or fat distribution in an individual.
• Inflammatory biomarkers: Indicators in the blood that reflect the presence of inflammation in the body.

Blueberry Supplementation and Insulin Sensitivity

• Daily supplementation with blueberry bioactives improved insulin sensitivity in obese, nondiabetic, and insulin-resistant individuals.
• The improvement in insulin sensitivity was observed without significant changes in adiposity, energy intake, or inflammatory biomarkers.

Study Design and Findings

• Participants consuming bioactives from blueberries showed a greater improvement in insulin sensitivity compared to the placebo group.
• The study emphasized the potential benefits of dietary supplementation with bioactives from whole blueberries for enhancing insulin sensitivity in at-risk individuals.